Reversing The Aging Process

Published Jul 21, 22
4 min read

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However, when fed a plasmalogen supplement, the aged mice took a shorter, quicker route to the platform than those not given the supplement – suggesting improved cognitive function. Credit: Lei Fu Synapses are a fundamental part of our neural networks and, therefore, crucial for learning and memory. Our synapses tend to be very plastic as children, but they decrease in number and deteriorate with age and in neurogenerative diseases, resulting in cognitive impairments.

It has been widely reported that the connection between the organisms in our gut and our brain influences neurodegeneration. It may be the plasmalogen’s effect on this connection that causes the improvements in learning and memory are seen in this study.” Professor Fu is so convinced by the results of this study that he takes a plasmalogen supplement each day.

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However, business mogul and Tesla CEO Elon Musk has a different approach to the research. David Sinclair, who has spent the last 20 years researching methods to reverse age, spoke to Life Itself, a health and wellness initiative in partnership with CNN and said, “If we reverse aging, these diseases should not happen.

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We can cure a mouse of almost any cancer, but most of those cures don’t work with humans.” In addition to this, Whitney Casey, an investor who is collaborating with Sinclair to develop a self-testing biological age test, claimed that Sinclair's study suggests that one can slow down the ageing process and live longer, however, presently, “he wants to change the world and make ageing a disease," CNN reported.

He went on to say, "We know that when we reverse the age of an organ like the brain in a mouse, the diseases of aging then go away. Memory comes back; there is no more dementia.” Furthermore, the scientists utilised proteins that were used to control gene expression, The Denver Channel reported.

While the modifications in mice lasted months, Sinclair explained that rejuvenated cells do not freeze in time and never age. He claimed, "It is as permanent as ageing is. It is a reset, and then we see the mice age out again, so then we just repeat the process." He also asserted that they believe they have discovered the main control switch, which would allow them to turn back the clock, CNN reported.

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The mice, as well as their young progeny, were able to see again. (Image: AP/ Unsplash).

Slowing down aging is great, but what about actually reversing aging? Reversing aging would mean making an old organism young again. Is it possible? What may come as a surprise to many, the answer is yes! In the last few years, scientists have shown that it’s actually possible to partially reverse aging: they succeeded in making old organisms younger.

Let’s start with a few biotech approaches to reverse aging, before we cover lifestyle interventions. Epigenetic rejuvenation The epigenome is the molecular machinery that determines which genes are switched on or off. Unfortunately, the older we get, the more the epigenome gets dysregulated. For example, cancer promoting genes are switched on (increasing our risk of cancer), and housekeeping and protective genes are switched off.

Scientists Make Further Inroads Into Reversing Ageing Process

Reversing Vision Loss By Turning Back The Aging ClockReversing The Aging Clock With Epigenetic Reprogramming

In one experiment, senescent cells were removed in old mice. These old mice looked younger again: their gray fur with bald spots became shiny and black again, and the organs and other tissues of these mice could regenerate or function better compared to when they were old (R). Other studies show that when senescent cells are destroyed, various aspects of aging can be improved (R,R,R).

The approaches we just mentioned are currently being developed to also be used in humans, but this will take many years (probably at least 15 years before we will see these technologies being used in humans). So, the ultimate question is, is it possible to partially reverse aging in humans now? Some studies have shown that it could already be possible to reverse aging in humans.

5 years (R,R). Other studies show that lifestyle interventions, including diet, exercise and supplements can reverse aging measured by epigenetic clocks. In one study, patients were put on a healthy diet, had to take specific supplements and exercise. After 8 weeks, their epigenetic age was reversed by almost 2 years (R).

Scientists Make Further Inroads Into Reversing Ageing Process

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These and other studies show that aging can be reversed. And not just aging, but also various aging-related diseases at the same time. For example, if people adhere to a very healthy diet, many cases of type 2 diabetes can be reversed, and even atherosclerosis. In one study, people who adhered to a more healthy diet, and had to exercise could reduce the atherosclerotic plaque in the coronary arteries of their heart, not needing a heart operation anymore (which they were recommended to undergo) (R).